- 簡介
- 科研領(lǐng)域
- 學術(shù)發(fā)表
個人簡介
北京大學基因功能研究與操控全國重點實驗室、現(xiàn)代農(nóng)學院、北京大學-清華大學生命科學聯(lián)合中心PI，博雅青年學者，博士生導師。中國遺傳學會細胞遺傳學分會委員，中國植物學會植物結(jié)構(gòu)與生殖專委會委員。主持多項國家自然科學基金面上項目、作為骨干參與國家科技創(chuàng)新2030重大項目、入選國家級青年人才項目。近年來已發(fā)表論文32篇，其中以第一作者或通訊作者發(fā)表論文19篇，包括Nature Genetics、Molecular Cell、Genome Biology、Nature Communications、PNAS、Plant Cell等。目前實驗室在讀博士研究生10名。
教育經(jīng)歷
2010年畢業(yè)于北京生命科學研究所（NIBS）與蘭州大學，獲博士學位；
2011年起，先后在美國梅奧醫(yī)學中心、德國馬克斯普朗克植物育種學研究所進行博士后/博士后研究員工作。
工作經(jīng)歷
2018年9月入職北京大學現(xiàn)代農(nóng)學院，同時加入蛋白質(zhì)與植物基因研究國家重點實驗室、北京大學-清華大學生命科學聯(lián)合中心（CLS）。
科研領(lǐng)域
植物研究是農(nóng)業(yè)科學的重要基石。本實驗室致力于系統(tǒng)解析表觀遺傳調(diào)控在植物生長發(fā)育中的核心作用，重點圍繞“表觀遺傳機制如何通過調(diào)控基因的時空特異性轉(zhuǎn)錄，進而控制植物發(fā)育”這一根本科學問題展開研究，旨在為作物遺傳改良提供理論框架。調(diào)控植物發(fā)育的絕大多數(shù)關(guān)鍵基因均受到表觀遺傳修飾的精確控制。只有深入揭示表觀遺傳網(wǎng)絡(luò)動態(tài)調(diào)控基因表達的機制，才能真正理解植物發(fā)育可塑性的分子基礎(chǔ)，這也是實現(xiàn)精準分子育種的關(guān)鍵前提。目前，農(nóng)業(yè)領(lǐng)域?qū)χ参锉碛^遺傳調(diào)控體系仍存在顯著認知空白：從組蛋白修飾的動態(tài)機制、三維染色質(zhì)結(jié)構(gòu)的組織規(guī)律，到表觀信息如何轉(zhuǎn)化為基因時空表達模式，均亟待系統(tǒng)闡明。針對這一核心方向，本實驗室聚焦于解析組蛋白修飾酶復合體的作用機制及其對染色質(zhì)結(jié)構(gòu)與基因轉(zhuǎn)錄的調(diào)控，并建立表觀遺傳動態(tài)變化與發(fā)育表型之間的分子網(wǎng)絡(luò)。
學術(shù)發(fā)表
1. Zhang, Y., Huang, R., Yang, T., Li, A., Wang, Z., Wu, Y., Deng, Y., Zhang, J., He, XQ, Zhou, Y. PRC2 regulates cytokinin and HD-ZIP III pathways to orchestrate vascular tissue pattern formation in Arabidopsis. Plant Cell, 8:koaf194.
2. Xiao, S., Luo, L., Yang, M., He, H., Zhou, Y. Fine-scale 3D chromatin architectures and their regulatory mechanisms in plants. Curr Opin Plant Biol, doi.org/10.1016/j.pbi.2025.102786.
3. Luo, L., Yang, M., Song, Z., Liu, Y., Xiao, S., Wang, D., Calonje, M., He, H., Zhou, Y (2025). PRC1-Mediated H2Aub Loop Formation and Function in Arabidopsis. Adv Sci 12: e2304377.
4. Shu, J., Xiao, S., Wang, D., Yang, M., Zhou, Y (2025). Protocol for capturing genome-wide chromatin interactions in Arabidopsis. STAR Protoc 6: 103702.
5. Liu, Y., Xiao, S., Yang, M., Guo, G., Zhou, Y (2025). The Impact of Polycomb Group Proteins on 3D Chromatin Structure and Environmental Stresses in Plants. Plants (Basel) 14: 1308. (Invited review)
6. Luo, L., Yang, M., Zhou, Y (2025). BMI1s interact with condensin complexes to regulate chromatin 3D structure and gene expression in Arabidopsis. aBIOTECH, 10.1007/s42994-025-00202-x.
7. Song, Z., Xia, Q., Yang, M., Yang, T., Liu, Y., Wang, D., Shu, J., Liu, Z., Chi, Y., Xu, H., Xing, D., Zhou, Y (2025). Dynamic changes in 3D chromatin structure during male gametogenesis in Arabidopsis thaliana. Genome Biol 26: 27.
8. Wang, D., Xiao, S., Shu, J., Luo, L., Yang, M., Calonje, M., He, H., Song, B., Zhou, Y (2024). Promoter capture Hi?C identifies promoter?related loops and fountain structures in Arabidopsis. Genome Biol 25: 324.
9. Shu, J., Sun, L., Wang, D., Yin, X., Yang, M., Yang, Z., Gao, Z., He, Y., Calonje, M., Lai, J., Deng, X. W., He, H., Zhou, Y (2024). EMF1 functions as a 3D chromatin modulator in Arabidopsis. Mol Cell 84: 4729-4739.
10. Yang, T., Wang, D., Luo, L., Yin, X., Song, Z., Yang, M., Zhou, Y (2024). PWOs repress gene transcription by regulating chromatin structures in Arabidopsis. Nucleic Acids Res 52: 12918-12929.
11. Yin, X., Romero-Campero, F. J., Yang, M., Baile, F., Cao, Y., Shu, J., Luo, L., Wang, D., Sun, S., Yan, P., Gong, Z., Mo, X., Qin, G., Calonje, M., Zhou, Y (2023). Binding by the Polycomb complex component BMI1 and H2A monoubiquitination shape local and long-range interactions in the Arabidopsis genome. Plant Cell 35: 2484-2503.
12. Yang, T., Wang, D., Tian, G., Sun, L., Yang, M., Yin, X., Xiao, J., Sheng, Y., Zhu, D., He, H., Zhou, Y (2022). Chromatin remodeling complexes regulate genome architecture in Arabidopsis. Plant Cell 34: 2638-2651.
13. Yin, X., Romero-Campero, F. J., de los Reyes, P., Yan, P., Yang, J., Tian, G., Yang, X., Mo, X., Zhao, S., Calonje, M., Zhou, Y (2021). H2AK121ub in Arabidopsis associates with a less accessible chromatin state at transcriptional regulation hotspots. Nat Commun 12: 315.
14. Zhou, Y., Wang, Y., Krause, K., Yang, T., Dongus, JA., Zhang, Y., Turck, F (2018). Telobox motifs recruit CLF/SWN-PRC2 for H3K27me3 deposition via TRB factors in Arabidopsis. Nature Genet 50: 638-644.
15. Zhou, Y., Tergemina, E., Cui, H., Forderer, A., Hartwig, B., James, GV., Scheeberger, K., Turck, F (2017). Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana. Proc Natl Acad Sci U S A 114: 4833-4838.
16. Zhou, Y., Romero-Campero, FJ., Gomez-Zambrano, A., Turck, F., Calonje, M (2017). H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity. Genome Biol 16: 69.
17. Zhou, Y., Hartwig, B., James, GV., Schneeberger, K., Turck, F (2016). Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. Plant Cell 28: 87-101.